Based on this road map and goals, we composed a document with our research focus for 2024. The key areas of interest are:

Pathway Grants:

– Autophagy/proteostasisSystem neuroscience (e.g., synaptic dysfunction or loss)
– Biological roles of GWAS hits
– Environmental causes and geographical clusters
– Nuclear architecture, epigenetics and transcription regulation
– Innate and adaptive immunity in tauopathies
– Mendelian families
– Validation of existing animal and human-derived preclinical models
– Sleep physiology
– Tau strains

Pipeline Grants:
– Validation of novel drug targets
– Cell replacement therapy/regenerative approaches
– Biomarker validation (diagnostic, disease progression, comorbidities)
– Prodromal and early-stage diagnostic markers
– Diagnostic platform validation (e.g., RT-QuIC)
– Proof-of-concept clinical trials
– Rehabilitation strategies for motor and nonmotor deficits
– RNA-based neuroprotection
– Symptomatic clinical drug trials
– Symptomatic clinical non-pharmacological trials

For further information contact Dr. Jennifer Brummet at brummet@curepsp.org 

The next grant deadline is October 3, 2024, at 5pm ET.

Grants will be submitted to ProposalCentral.

Grant instructions can be found here.

Through the Pathway and Pipeline Grant program, CurePSP provides seed funding to investigators who have innovative ideas that need proof of concept or pilot studies in order to qualify for larger funding sources. CurePSP provides grants to scientists of up to $100,000 for one- or two-year studies. Proposals are carefully evaluated by our Scientific Advisory Board (SAB) in collaboration with our Executive Director and the Board of Directors.

CurePSP will fund studies on PSP and CBD through two avenues, the pathway grants or pipeline grants program.

Pathway grants support projects studying the fundamental neurobiology of PSP and CBD.  A more complete understanding of the underlying basic science and mechanisms of PSP and CBD will improve understanding of the diseases and provide the foundation for future treatments. Studies focusing on mechanisms common to multiple neurogenerative are strongly encouraged.

Examples of pathway grant topics include (but are not limited to) tau biology and pathobiology, epigenetics and epigenomics, synaptic dysfunction/lost and pruning, neuroinflammation, organoids, or other underlying mechanisms of PSP or CBD.

Pipeline grants support translational projects focusing on new therapeutics and biomarkers for PSP and CBD. These projects will accelerate the development of therapeutics that have the potential to prevent, treat, or cure PSP and CBD by accelerating the translation of basic science discoveries into novel therapeutics.

Examples of pipeline grant topics include (but are not limited to) symptomatic drug trials, diagnostic markers, or rehabilitation strategies for motor and nonmotor deficits. 

CurePSP provides grants to scientists of up to $100,000 for one- or two-year studies. Proposals are carefully evaluated by our Scientific Advisory Board (SAB) in collaboration with our Executive Director and the Board of Directors.

These studies offer donors the opportunity to name and be involved with hand-selected and intensively administered research that provides the greatest return on investment for the donor dollar.

Please visit our currently funded research grants page to learn more about currently funded research. 

Please visit our completed research grants to learn more about completed research studies.

CurePSP supports large research projects conducted by leading senior investigators at major institutions. These studies may have a longer time horizon and broader scope than our Venture Grants, and may involve joint funding from other sources. These studies have the potential of making major strides in the quest to find treatment and cure for neurodegeneration and as such provide significant opportunities for donor recognition and involvement.

Please visit our Enterprise Grants page to learn more about this research. 

CurePSP Student Fellowships support students and trainees conducting summer research projects focused on PSP, CBD or MSA. The goal of these programs is to encourage trainees to pursue research in this field in an effort to make PSP, CBD and MSA a long-term area of research interest and to further our understanding of these diseases

Please visit our Student Fellowship page to learn more. 

The Alzheimer’s Association, The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and CurePSP are partnering together on this unique funding program to advance an understanding of the role sleep plays in neurodegeneration, including Alzheimer’s disease, Parkinson’s disease, Lewy body diseases and Progressive Supranuclear Palsy. This funding call will focus on projects aimed to advance our understanding of the impact that sleep and related biology (including circadian rhythms) have as both a contributor to and a consequence of neurodegeneration. Projects funded through this program will aim to tackle the proposed question with a multidisciplinary team and projects that engage in team science approaches will be given preference. 

Please visit this page to learn more.