Mechanisms of Sleep Disturbances in a Mouse Model of Tauopathy

Pathway Grant

Principal Investigator: Dr. Peng Zhong, University of Nebraska Medical Center

Sleep problems and progressive supranuclear palsy (PSP) are interrelated and bidirectional. A range of sleep disorders affect half of patients with PSP and are thought to contribute to disease progression. Understanding sleep circuitry abnormalities in PSP could improve our understanding of its neuropathology and provide insight into the novel therapeutic approaches for this neurodegenerative disease. This proposal will utilize the powerful systems neuroscience techniques to provide an integrated approach for studying whether and how lateral hypothalamic sleep-wake neurons become dysfunctional in the tauopathy condition of PSP.